Treatment of high urate turnover conditions, e. Dosage of Zyloric should be at the lower end of the recommended dosage schedule. If urate allopurinol or other pathology has compromised renal function, the advice given in section 4. See also section 4. Method of administration Zyloric may be taken orally once a day after a meal. It is well tolerated, especially after food. Should the daily dosage exceed mg and gastrointestinal intolerance be manifested, a divided doses regimen may be appropriate.
These reactions are clinical diagnoses, and their clinical presentations remain the basis for decision making. If such reactions occur at any time during treatment, allopurinol should be withdrawn immediately. Corticosteroids may be beneficial in overcoming hypersensitivity skin reactions. The use of genotyping has not been established buy diclofenac 50mg tablets other patient populations.
Hepatic or renal impairment Reduced doses should be used in patients with hepatic or renal impairment see Section 4. Patients under treatment for hypertension or 300mg insufficiency, for example with diuretics or ACE inhibitors, may have some concomitant impairment of renal function and allopurinol should be used with care in this group.
Asymptomatic hyperuricaemia Asymptomatic hyperuricaemia per se is generally not considered an indication for use of Zyloric. Fluid and dietary modification with management of the underlying cause may correct the condition. Acute gouty attacks Allopurinol treatment should not be started until an acute attack of gout has completely subsided, as further attacks may be precipitated. In the early stages of treatment with Zyloric, as with uricosuric agents, an acute attack of gouty arthritis may be precipitated.
Therefore it is advisable to give prophylaxis with a suitable anti-inflammatory agent or colchicine for at least one month. The literature should be consulted for details of appropriate dosage and precautions and warnings.
If acute attacks develop in patients receiving allopurinol, treatment should continue at the same dosage while the acute attack is treated with a suitable anti-inflammatory agent. Xanthine deposition In conditions where the rate of urate formation is greatly increased e. This risk may be minimised by adequate hydration to achieve optimal urine dilution, zyloric allopurinol 300mg.
Impaction of uric acid renal stones Adequate therapy with Zyloric will lead to dissolution of large uric acid renal pelvic stones, with the remote possibility of impaction in the ureter. Caution is required when allopurinol is used in patients with alteration of thyroid allopurinol. Lactose Zyloric tablets contain lactose and therefore should not be administered to patients with rare hereditary problems of galactose intolerance, zyloric allopurinol 300mg, the Lapp lactase deficiency or glucose-galactose malabsorption.
Therefore, a dose of allopurinol per day or mg twice a week, or perhaps less, may be zyloric to maintain adequate xanthine oxidase inhibition to reduce serum urate levels. Bone marrow depression has been reported in patients receiving ZYLOPRIM allopurinolmost of whom received concomitant drugs with the potential for causing this reaction, zyloric allopurinol 300mg. The correct dosage precio pastillas cytotec farmacias ahorro schedule for maintaining the serum uric acid within the normal range is best determined by using the serum uric acid allopurinol an index.
ZYLOPRIM allopurinol and its primary active metabolite, oxipurinol, are eliminated by the kidneys; therefore, changes in 300mg function have a profound effect on dosage. In patients with decreased renal function or who have concurrent illnesses which can affect renal function such as hypertension and diabetes mellitusperiodic laboratory parameters of renal function, particularly BUN and serum creatinine or creatinine clearance, should be performed and the patient’s dosage of ZYLOPRIM allopurinol reassessed.
There were increased numbers of external malformations in fetuses at both doses of allopurinol on gestation day 10 and 300mg numbers of skeletal malformations in fetuses at both doses on gestation day It cannot be determined whether this represented a fetal effect or an effect secondary 300mg maternal toxicity.
There are, however, no adequate or well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. There are two unpublished reports and one published paper of women giving birth to normal offspring after receiving ZYLOPRIM allopurinol during pregnancy.
Since the effect of allopurinol on the nursing infant is unknown, caution should be exercised when ZYLOPRIM allopurinol is administered to a nursing woman, zyloric allopurinol 300mg. Zyloric reduces the production of uric acid by inhibiting the biochemical reactions mmediately preceding its formation. It is an inhibitor of xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine and of xanthine to uric acid, the end product of purine metabolism in man.
ZYLOPRIM allopurinol is metabolized to the corresponding zyloric analogue, oxipurinol alloxanthinewhich also is an inhibitor of xanthine oxidase. It has been shown that reutilization of both hypoxanthine and xanthine for nucleotide and nucleic acid synthesis is markedly enhanced when their oxidations are inhibited by ZYLOPRIM allopurinol and oxipurinol. This zyloric does not disrupt normal nucleic acid anabolism, however, because feedback inhibition is an integral part of purine biosynthesis.
As a result of xanthine oxi-dase inhibition, the serum concentration of hypoxanthine plus xanthine in patients receiving ZYLOPRIM allopurinol for treatment of hyperuricemia is usually in the range of 0.
A maximum of 0. The renal clearance of hypoxanthine and xanthine is at least 10 times greater than that of uric acid.